It is a branch that emerges from pharmacology, whose main objective is to study the effects caused by the physicochemical formula and the form of drugs on the pharmacodynamic and pharmacokinetic events after their use. During the last decades this science has gained ground and gained great importance, all this thanks to the inevitable need to carry out bioequivalence studies of interchangeable generic drugs.
The purpose of the study of biopharmacy rests on determining the most appropriate amounts or doses, as well as the intervals between doses to optimally administer medications. On the other hand, it also allows knowing and performing the most exact calculations regarding the concentration of drugs in the different organs of the body, in order to establish an optimal therapy regimen.
The characteristic processes regarding the development of a drug after administration in a certain organism under specific conditions and under a strict administration regimen are known by the initials LADME, whose acronyms come from the stages through which the drug can go through During the passage of the drug through the body, the first of these stages is the release of the drug, the second is absorption, followed by distribution, leading to metabolization and finally excretion.
The release, refers to the exit of the drug from its pharmaceutical presentation, generally this process dilutes the medicine in some medium of the body, through the appropriate application of certain technical pharmacological processes, the speed can be controlled with the the medicine is released.
Absorption, during this process it can be said that it is when the medicine actually enters the body, where it crosses different membranes, this before reaching a systemic circulation.
Distribution, after the drug enters the circulatory system, it is spread throughout the body through the blood, once the drug is in the vascular space, the drug can bind with plasma proteins and also pass through erythrocytes among other cells.
Metabolization, in this stage the drug will undergo certain modifications in its structure, this due to the effect of the enzymatic systems of the body, as a result, metabolites a little more soluble and with less activity than in the beginning can be obtained.
Excretion, after the drug enters the circulatory system, the body detects the foreign substances and initiates the different processes for their elimination.
